Calsequestrin antibody (AA 100-250)

Catalog No. ABIN6942360

This Rabbit Monoclonal antibody specifically detects Calsequestrin in IF (cc), FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Calsequestrin antibody (AA 100-250) (ABIN6942360)

Target: Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Calsequestrin antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 8G1

Product Details anti-Calsequestrin Antibody

Binding Specificity: AA 100-250

Purpose: Calsequestrin-1 (8G1) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human Calsequestrin 1 aa 100-250

Isotype: IgG

Application Details

Application Notes: FCM(1:300-5000), IHC-P(1:200-400), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calsequestrin

Target: Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))

Alternative Name: CASQ1

Background:

Synonyms: Calsequestrin 1, Calmitine, Calsequestrin skeletal muscle isoform, CASQ1, CASQ, PDIB1, VMCQA

Background: The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.

Gene ID: 844

UniProt: P31415