CYP8B1 antibody (AA 151-250) (Biotin)

Catalog No. ABIN6942792

This Rabbit Polyclonal antibody specifically detects CYP8B1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for CYP8B1 antibody (AA 151-250) (Biotin) (ABIN6942792)

Target: CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP8B1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CYP8B1 Antibody (Biotin)

Binding Specificity: AA 151-250

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYP8B1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CYP8B1

Target: CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1))

Alternative Name: CYP8B1

Background:

Synonyms: 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, CP8B1_HUMAN, CYP12, CYP8B1, CYPVIIIB1, Cytochrome P450 8B1, Cytochrome P450, family 8, subfamily B, polypeptide 1, Sterol 12-alpha-hydroxylase.

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

Gene ID: 1582

UniProt: Q9UNU6