Dynamin 1-Like antibody (pSer616) (Cy5)

Catalog No. ABIN6943128

This Rabbit Polyclonal antibody specifically detects Dynamin 1-Like in IF (cc) and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for Dynamin 1-Like antibody (pSer616) (Cy5) (ABIN6943128)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Dynamin 1-Like Antibody (Cy5)

Binding Specificity: pSer616

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human DRP1 around the phosphorylation site of Ser616

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DRP1

Background:

Synonyms: DRP1 (phospho S616), p-DRP1 (phospho S616), P-DRP1 (Ser616), DLP1, dnm1l, DNM1L_HUMAN, Dnm1p/Vps1p-like protein, DVLP, Dymple, Dynamin 1 like, Dynamin family member proline-rich carboxyl-terminal domain less, Dynamin like protein, Dynamin related protein 1, Dynamin-1-like protein, Dynamin-like protein 4, Dynamin-like protein, Dynamin-like protein IV, Dynamin-related protein 1, DYNIV 11, FLJ41912, HdynIV, VPS1.

Background: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Gene ID: 10059

UniProt: O00429