EEFSEC antibody (AA 21-120)

Catalog No. ABIN6943211

The Rabbit Polyclonal anti-EEFSEC antibody (ABIN6943211) specifically detects EEFSEC in IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for EEFSEC antibody (AA 21-120) (ABIN6943211)

Target: EEFSEC (Eukaryotic Elongation Factor, Selenocysteine-tRNA-Specific (EEFSEC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EEFSEC antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-EEFSEC Antibody

Binding Specificity: AA 21-120

Purpose: EEFSEC Polyclonal Antibody

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EEFSEC

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for EEFSEC

Target: EEFSEC (Eukaryotic Elongation Factor, Selenocysteine-tRNA-Specific (EEFSEC))

Alternative Name: EEFSEC

Background:

Synonyms: EFSEC, SELB_HUMAN_ Elongation factor for selenoprotein translation, Elongation factor sec, Eukaryotic elongation factor, selenocysteine tRNA specific, SELB, Selenocysteine specific elongation factor.

Background: EEFSEC is a 596 amino acid protein that localizes to both the nucleus and the cytoplasm and belongs to the GTP-binding elongation factor family. Functioning as a translation factor, SELB binds GTP and GDP and is necessary for the incorporation of selenocysteine into target proteins. The gene encoding SELB maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Gene ID: 60678

UniProt: P57772