Recombinant Complement Factor H antibody

Catalog No. ABIN6943395

This Rabbit Monoclonal antibody specifically detects Complement Factor H in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant Complement Factor H antibody (ABIN6943395)

Target: Complement Factor H (CFH)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Complement Factor H antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Complement Factor H Antibody

Purpose: CFH Recombinant Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Full length protein

Isotype: IgG

Application Details

Application Notes: WB(WB(1:500-2000))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Complement Factor H

Target: Complement Factor H (CFH)

Alternative Name: Factor H

Background:

Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

Gene ID: 3075

UniProt: P08603

Pathways: Complement System, Cellular Response to Molecule of Bacterial Origin