HDAC2 antibody

Catalog No. ABIN6943609

The Mouse Monoclonal anti-HDAC2 antibody has been validated for WB, ELISA, IF (cc), ChIP-seq and DB. It is suitable to detect HDAC2 in samples from Human.

Quick Overview for HDAC2 antibody (ABIN6943609)

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), ChIP DNA-Sequencing (ChIP-seq), Dot Blot (DB)

Clone: 7G5

Product Details anti-HDAC2 Antibody

Cross-Reactivity: Human

Purification: Protein A purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300

Immunogen: Monoclonal antibody raised in mouse against human HDAC2 (Histone deacetylase 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IF(ICC) 1:50-200
dot-blot()
ChIP-seq()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Alternative Name: HDAC2

Background:

Synonyms: HD2, RPD3, YAF1

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Gene ID: 3066

UniProt: Q92769

Pathways: Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection