IKZF1 antibody
Quick Overview for IKZF1 antibody (ABIN6943787)
Target
See all IKZF1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
-
-
Cross-Reactivity
- Human, Mouse
-
Purification
- Purified by Protein A.
-
Immunogen
- Recombinant protein within human Ikaros aa 250-450
-
Isotype
- IgG
-
-
-
-
Application Notes
-
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400 -
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- 1 μg/μL
-
Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
-
Preservative
- ProClin
-
Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
Storage
- 4 °C,-20 °C
-
Storage Comment
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
Expiry Date
- 12 months
-
-
- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
-
Alternative Name
- IKZF1
-
Background
-
Synonyms: DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1, IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Background: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms
-
Gene ID
- 10320
-
UniProt
- Q13422
-
Pathways
- Production of Molecular Mediator of Immune Response
Target
-