MLKL antibody

Catalog No. ABIN6944094

This Rabbit Monoclonal antibody specifically detects MLKL in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for MLKL antibody (ABIN6944094)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLKL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 3G4

Product Details anti-MLKL Antibody

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: Human MLKL between 350 to C-terminus

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Synonyms: Mixed lineage kinase domain-like protein, hMLKL, MLKL

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).

Gene ID: 197259

UniProt: Q8NB16