Recombinant MMP13 antibody

Catalog No. ABIN6944105

The Rabbit Monoclonal anti-MMP13 antibody (ABIN6944105) specifically detects MMP13 in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant MMP13 antibody (ABIN6944105)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MMP13 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MMP13 Antibody

Purpose: MMP13 Recombinant Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: N terminus human MMP13

Isotype: IgG

Application Details

Application Notes: WB(WB(1:500-2000))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: MMP13

Background:

Synonyms: Collagenase 3, Matrix metalloproteinase-13, MMP-13, MMP13

Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Gene ID: 4322

UniProt: P45452