This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Synonyms: Antigen NY CO 31, Antigen NY-CO-31, FLJ25475, Inhibitory NADPH oxidase activator 1, MGC131800, NADPH oxidase activator 1, NCF2 like protein, NCF2-like protein, NOX activator 1, NOXA 1, Noxa1, NOXA1_HUMAN, NY CO 31, p51 nox, p51-nox, p51NOX, P67phox like factor, P67phox-like factor, SDCCAG31, Serologically defined colon cancer antigen 31.