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PKC iota antibody (AA 181-280) (HRP)

The Rabbit Polyclonal anti-PKC iota antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect PKC iota in samples from Human and Mouse.
Catalog No. ABIN6944557

Quick Overview for PKC iota antibody (AA 181-280) (HRP) (ABIN6944557)

Target

See all PKC iota (PRKCI) Antibodies
PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Reactivity

  • 34
  • 26
  • 6
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Mouse

Host

  • 30
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Rabbit

Clonality

  • 30
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Polyclonal

Conjugate

  • 16
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This PKC iota antibody is conjugated to HRP

Application

  • 33
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  • 11
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 7
    • 2
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    AA 181-280

    Cross-Reactivity

    Human, Mouse

    Predicted Reactivity

    Rat,Cow,Sheep,Pig,Horse

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human PKC iota/PKCI

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

    Alternative Name

    PKC iota

    Background

    Synonyms: aPKC lambda/iota, aPKC-lambda/iota, Atypical protein kinase C lambda/iota, Atypical protein kinase C-lambda/iota, DXS1179E, KPCI_HUMAN, MGC26534, nPKC iota, nPKC-iota, nPKCiota, PKC lambda, PKCI, PKCiota, PKClambda, PRKC iota, PRKC lambda/iota, PRKC-lambda/iota, PRKCI, Protein kinase C iota, Protein kinase C iota type.

    Background: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

    Gene ID

    5584

    UniProt

    P41743

    Pathways

    Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation
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