Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB) antibody

Details for Product No. ABIN6944649
Antigen
  • PP-1B
  • PP1B
  • PP1beta
  • PPP1CD
  • 1200010B19
  • ik:tdsubc_2f2
  • si:zc214p16.4
  • wu:fa09h01
  • wu:fa11e06
  • xx:tdsubc_2f2
  • PP2CB
  • Ppp1cb
  • protein phosphatase 1 catalytic subunit beta
  • protein phosphatase 1, catalytic subunit, beta isoform
  • protein phosphatase 1, catalytic subunit, beta isozyme L homeolog
  • protein phosphatase 1, catalytic subunit, beta isozyme
  • serine/threonine-protein phosphatase PP1-beta catalytic subunit
  • protein phosphatase 1B, magnesium dependent, beta isoform
  • PPP1CB
  • Ppp1cb
  • ppp1cb.L
  • ppp1cb
  • LOC100224238
  • Ppm1b
Reactivity
Human, Mouse (Murine), Rat (Rattus)
128
69
49
13
8
7
6
5
5
5
4
4
3
3
3
1
1
1
Host
Rabbit
110
18
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
6
6
4
4
4
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
102
64
31
12
11
8
3
2
2
2
1
Options
Immunogen Recombinant protein corresponding to human PPP1CB aa 100-327.
Clone 6G6
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PPP1CB (PPP1CB Antibody Abstract)
Background

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

Subcellular location: Cytoplasm, Nucleus


Synonyms: Serine/threonine-protein phosphatase PP1-beta catalytic subunit, Protein phosphatase 1 catalytic subunit beta, PP-1B, PPP1CD, PP1beta
Gene ID 5500
UniProt P62140
Pathways M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism
Application Notes WB(1:1000-10000), IHC-P(1:50-200), IP(1:50-100)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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