PPP1CB antibody (Catalytic Subunit)

Catalog No. ABIN7169308

The Rabbit Polyclonal anti-PPP1CB antibody (ABIN7169308) specifically detects PPP1CB in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for PPP1CB antibody (Catalytic Subunit) (ABIN7169308)

Target: PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1CB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PPP1CB Antibody

Binding Specificity: AA 175-221, Catalytic Subunit

Purpose: PPP1CB Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Serine/threonine-protein phosphatase PP1-beta catalytic subunit protein (175-221AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPP1CB

Target: PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))

Alternative Name: PPP1CB

Background:

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the \\\'Ser-418\\\' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Aliases: MGC3672 antibody, PP 1B antibody, PP-1B antibody, PP1B antibody, PP1B_HUMAN antibody, PP1beta antibody, PPP1CB antibody, PPP1CD antibody, Protein phosphatase 1 beta antibody, Protein phosphatase 1 catalytic subunit beta isoform antibody, Protein phosphatase 1 delta antibody, Protein phosphatase 1, catalytic subunit, beta isozyme antibody, Protein phosphatase 1, catalytic subunit, delta isoform antibody, Serine threonine protein phosphatase PP1 beta catalytic subunit antibody, Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody

UniProt: P62140

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism