STAU1/Staufen antibody (AA 400-550)

Catalog No. ABIN6945068

The Rabbit Monoclonal anti-STAU1/Staufen antibody (Clone 8C8) (ABIN6945068) specifically detects STAU1/Staufen in WB, FACS and IF (cc). The antibody is reactive with Human samples.

Quick Overview for STAU1/Staufen antibody (AA 400-550) (ABIN6945068)

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STAU1/Staufen antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 8C8

Product Details anti-STAU1/Staufen Antibody

Binding Specificity: AA 400-550

Purpose: Staufen (8C8) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human Staufen aa 400-550

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), FCM(1:20-100), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for STAU1/Staufen

Target: STAU1/Staufen (STAU1) (Staufen Double-Stranded RNA Binding Protein 1 (STAU1))

Alternative Name: STAU1

Background:

Synonyms: Double-stranded RNA-binding protein Staufen homolog 1, PPP1R150, STAU1, STAU.

Background: STAU1 (staufen, RNA binding protein, homolog 1) is a 577 amino acid protein that contains three double-stranded RNA-binding domains and is a mammalian homolog of Staufen, a Drosophila protein that is involved in mRNA transport during oogenesis and zygotic development. Localized to the rough endoplasmic reticulum (RER) and expressed in a variety of tissues, including heart, brain, liver, lung, pancreas, kidney and placenta, STAU1 binds to both Tubulin and double-stranded RNA and is thought to play an important role in mRNA transport from the microtubule network to the RER. Additionally, STAU1 may be involved in cross-linking cytoskeletal components with RNA, an event that is important for proper mRNA positioning during translation. Alternative splicing of the STAU1 gene yields two STAU1 isoforms, designated short and long.

Gene ID: 6780

UniProt: O95793

Pathways: Asymmetric Protein Localization