STIM1 antibody (AA 1-600)

Catalog No. ABIN6945088

The Rabbit Monoclonal anti-STIM1 antibody is suitable to detect STIM1 in samples from Human, Rat and Mouse. It has been validated for WB, IHC and IHC (p).

Quick Overview for STIM1 antibody (AA 1-600) (ABIN6945088)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7C4

Product Details anti-STIM1 Antibody

Binding Specificity: AA 1-600

Purpose: Stromal interaction molecule 1 (7C4) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Human Stromal interaction molecule 1 between 1-600 amino acids

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400), IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Alternative Name: Stromal interaction molecule 1

Background:

Synonyms: Stromal interaction molecule 1, STIM1

Background: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Gene ID: 6786

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling