PLAT antibody (AA 401-500) (Biotin)

Catalog No. ABIN6945199

The Rabbit Polyclonal anti-PLAT antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect PLAT in samples from Mouse.

Quick Overview for PLAT antibody (AA 401-500) (Biotin) (ABIN6945199)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PLAT Antibody (Biotin)

Binding Specificity: AA 401-500

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Tissue-type plasminogen activator chain B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: TPA

Background:

Synonyms: TPA Tissue Plasminogen Activator, Alteplase, DKFZp686I03148, Plasminogen activator tissue, Plasminogen activator tissue type, PLAT, Reteplase, t PA, T Plasminogen Activator, t-PA, T-plasminogen activator, Tissue plasminogen activator (t PA), Tissue type plasminogen activator, Tissue-type plasminogen activator chain B, tPA, TPA_HUMAN, TPA1.

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene ID: 5327

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome