Recombinant PRNP antibody

Catalog No. ABIN6944654

The Rabbit Monoclonal anti-PRNP antibody (ABIN6944654) specifically detects PRNP in WB, FACS, IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for Recombinant PRNP antibody (ABIN6944654)

Target: PRNP (Prion Protein (PRNP))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PRNP antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PRNP Antibody

Purpose: PRNP Recombinant Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: C terminal human Prion protein

Isotype: IgG

Application Details

Application Notes: WB(WB(1:500-2000)), FCM(FCM(1:50-100)), IHC-P(IHC-P(1:50-200)), IHC-F(IHC-F(1:50-200)), IF(IHC-P)(IF(IHC-P)(1:50-200)), IF(ICC)(IF(ICC)(1:50-200))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PRNP

Target: PRNP (Prion Protein (PRNP))

Alternative Name: Prion Protein (PrP)

Background:

Synonyms: Major prion protein, ASCR, PrP27-30, PrP33-35C, CD_antigen: CD230, PrP, PRNP

Background: The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).

Gene ID: 5621

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation