PSMA antibody

Catalog No. ABIN6950897

The Mouse Monoclonal anti-PSMA antibody (ABIN6950897) specifically detects PSMA in IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PSMA antibody (ABIN6950897)

Target: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PSMA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PSMA Antibody

Purpose: Prostate Specific Membrane Antigen (PSMA) mouse mAb

Specificity: The antibody can specifically recognize human PSMA protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 100 - 200 of the human Prostate Specific Membrane Antigen protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for PSMA

Target: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Alternative Name: PSMA

Background:

Synonyms: Cell growth inhibiting protein 27, Cell growth-inhibiting gene 27 protein, FGCP, Folate hydrolase (prostate-specific membrane antigen) 1, Folate hydrolase 1, Folate hydrolase, Folate hydrolase prostate specific membrane antigen 1, FOLH 1, FOLH, Folh1, FOLH1_HUMAN, Folylpoly gamma glutamate carboxypeptidase, Folylpoly-gamma-glutamate carboxypeptidase, GCP 2, GCP II, GCP2, GCPII, GIG27, Glutamate carboxylase II, Glutamate carboxypeptidase 2, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, mGCP, N acetylated alpha linked acidic dipeptidase 1, N-acetylated-alpha-linked acidic dipeptidase I, NAALAD 1, NAALAD1, NAALAdase, NAALADase I, Prostate specific membrane antigen, Prostate specific membrane antigen variant F, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly gamma glutamate carboxypeptidase, Pteroylpoly-gamma-glutamate carboxypeptidase

Background: PSMA is a 110 kDa type II transmembrane protein. The gene is located in 11q and is expressed in normal and neoplastic prostate epithelium, as well as in breast, duodenum, colonic mucosa, kidney and tumors of its origin. The expression of PSMA increased after cell carcinogenesis, which was positively correlated with tumor grade and hormone resistance. Combined with PSA can improve the diagnosis of prostate cancer metastasis.

Gene Name: FOLH1

Protein Name: Prostate Specific Membrane Antigen

Gene ID: 2346

UniProt: Q04609