Retinoic Acid Receptor alpha antibody (C-Term)

Catalog No. ABIN6952387

The Rabbit Polyclonal anti-Retinoic Acid Receptor alpha antibody (ABIN6952387) specifically detects Retinoic Acid Receptor alpha in WB, ELISA, ChIP and ChIP-seq. The antibody is reactive with Human samples.

Quick Overview for Retinoic Acid Receptor alpha antibody (C-Term) (ABIN6952387)

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoic Acid Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Product Details anti-Retinoic Acid Receptor alpha Antibody

Binding Specificity: C-Term

Specificity: Polyclonal antibody raised in rabbit against human RARA (Retinoic Acid Receptor alpha) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein.

Purification: whole antiserum

Immunogen: synthetic peptide

Application Details

Application Notes: ChIP/ChIP-seq 4 μL:ChIP
ELISA 1:50
WB 1:750

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: serum, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Retinoic Acid Receptor alpha

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Alternative Name: RARA

Background: RARA (UniProtKB/Swiss-Prot entry P10276) is a receptor for retinoic acid, a vitamin A metabolite, which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand, this receptor represses transcription through the recruitment of specific corepressors and of HDAC's, whereas binding of retinioc acid causes the recruitment of coactivators and HAT's. Translocations involving the RARA gene, often leading to a RARA/PML fusion protein, are a major cause of acute promyelocytic leukemia.

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins