SIRPA antibody (AA 31-370)

Catalog No. ABIN6961045

This anti-SIRPA antibody is a Rabbit Monoclonal antibody detecting SIRPA in FACS, ELISA, IP and IF. Suitable for Human.

Quick Overview for SIRPA antibody (AA 31-370) (ABIN6961045)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SIRPA antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: DM8

Product Details anti-SIRPA Antibody

Binding Specificity: AA 31-370

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human SIRPalpha (Glu31-Arg370) (ABIN6961082) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: Flow Cyt  1/100, IP 1/30

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Alternative Name: SIRPalpha

Background: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Molecular Weight: 55 kDa

Gene ID: 140885

UniProt: P78324