Catalase antibody (AA 23-226)

Catalog No. ABIN6961050

The Rabbit Monoclonal anti-Catalase antibody has been validated for ELISA, IP, IF and FACS. It is suitable to detect Catalase in samples from Human.

Quick Overview for Catalase antibody (AA 23-226) (ABIN6961050)

Target: Catalase (CAT)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Catalase antibody is un-conjugated

Application: ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: DM9

Product Details anti-Catalase Antibody

Binding Specificity: AA 23-226

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human CS1 (Ser23-Met226) (ABIN6961075) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: Flow Cyt  1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for Catalase

Target: Catalase (CAT)

Alternative Name: CS1

Background: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).

Molecular Weight: 37 kDa

Gene ID: 57823

UniProt: Q9NQ25

Pathways: Cellular Glucan Metabolic Process, Cell RedoxHomeostasis, Photoperiodism