KLRG1 antibody

Catalog No. ABIN6961764

Product Details anti-KLRG1 Antibody

Target: KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))

Reactivity: Mouse

Host: Golden Syrian Hamster

Clonality: Monoclonal

Conjugate: This KLRG1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Purification: This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.

Clone: 2F1

Isotype: IgG

Application Details

Application Notes: This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.

Comment:

0.5 mg/mL

Restrictions: For Research Use only

Handling

Buffer: 10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C

Expiry Date: 12 months

Target Details for KLRG1

Target: KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))

Alternative Name: KLRG1 (KLRG1 Products)

Synonyms: KLRG1 antibody, 2F1-Ag antibody, MAFA antibody, MAFA-L antibody, 2F1 antibody, CLEC15A antibody, MAFA-2F1 antibody, MAFA-LIKE antibody, killer cell lectin like receptor G1 antibody, killer cell lectin-like receptor subfamily G, member 1 antibody, KLRG1 antibody, Klrg1 antibody

Background: The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

Gene ID: 50928

UniProt: O88713