IL-12/IL-23 p40 antibody

Catalog No. ABIN6964022

Product Details anti-IL-12/IL-23 p40 Antibody

Target: IL-12/IL-23 p40

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-12/IL-23 p40 antibody is un-conjugated

Application: Neutralization (Neut)

Specificity: Native and recombinant p40 subunit of mouse IL-12 and IL-23. The antibody recognizes p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40+p35) and IL-23 heterodimer (p40+p19).

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Immunogen: Recombinant mouse IL-12 p70

Clone: C17-8

Isotype: IgG2a

Application Details

Application Notes: Neutralization of mouse IL-12 and IL-23 bioactivity. It is recommended to establish the optimal antibody concentration for the assay system used. The antibody is also suitable for immunoassays.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: supplied at 1 mg/mL in PBS free of preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-IL-12/IL-23 p40 antibody (ABIN6964022)

Prabhakara, Harro, Leid, Keegan, Prior, Shirtliff: "Suppression of the inflammatory immune response prevents the development of chronic biofilm infection due to methicillin-resistant Staphylococcus aureus." in: Infection and immunity, Vol. 79, Issue 12, pp. 5010-8, (2012) (PubMed).

Lee, Hoeman, Hardaway, Guloglu, Ellis, Jain, Divekar, Tartar, Haymaker, Zaghouani: "Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity." in: The Journal of experimental medicine, Vol. 205, Issue 10, pp. 2269-80, (2008) (PubMed).

Chackerian, Chen, Brodie, Mattson, McClanahan, Kastelein, Bowman: "Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection." in: Infection and immunity, Vol. 74, Issue 11, pp. 6092-9, (2006) (PubMed).

Target Details for IL-12/IL-23 p40

Target: IL-12/IL-23 p40

Alternative Name: IL12/23 (p40) (IL-12/IL-23 p40 Products)

Gene ID: 16160