DROSHA antibody (C-Term)

Catalog No. ABIN6971610

The Rabbit Polyclonal anti-DROSHA antibody is suitable to detect DROSHA in samples from Human. It has been validated for WB and IP.

Quick Overview for DROSHA antibody (C-Term) (ABIN6971610)

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DROSHA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-DROSHA Antibody

Binding Specificity: C-Term

Characteristics: Drosha is an RNAse III enzyme that is involved in the process of generating microRNA (miRNA). miRNA interacts with the RNA-induced silencing complex (RISC) to cleave mRNA and thus downregulate gene expression. Drosha is a double stranded RNAse and part of the Microprocessor complex. Other RNAse III enzymes include Dicer and Argonaute. Drosha initiates processing of the miRNA precursor (pri-miRNA) in the nucleus, which is then exported to the cytoplasm and further cleaved by Dicer into a mature miRNA. Drosha antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogen: This Drosha antibody was raised against a peptide within the C-terminal region of human Drosha.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for DROSHA

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Alternative Name: Drosha

Molecular Weight: 160 kDa

NCBI Accession: NP_037367

Pathways: Regulatory RNA Pathways