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YAP1 antibody (C-Term)

The Rabbit Polyclonal anti-YAP1 antibody has been validated for WB and IP. It is suitable to detect YAP1 in samples from Human.
Catalog No. ABIN6972915

Quick Overview for YAP1 antibody (C-Term) (ABIN6972915)

Target

See all YAP1 Antibodies
YAP1 (Yes-Associated Protein 1 (YAP1))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This YAP1 antibody is un-conjugated

Application

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Western Blotting (WB), Immunoprecipitation (IP)
  • Binding Specificity

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    C-Term

    Characteristics

    YAP1 (Yes-associated protein 1, YAP, YKI, YAP2, YAP65) is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Is a critical modulator of epidermal stem cell proliferation. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. YAP1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.

    Purification

    Affinity Purified

    Immunogen

    This YAP1 antibody was raised against a peptide corresponding to the C-terminal region of human YAP1.

    Isotype

    IgG
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Buffer

    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target

    YAP1 (Yes-Associated Protein 1 (YAP1))

    Alternative Name

    YAP1

    Molecular Weight

    75 kDa

    NCBI Accession

    NP_001123617

    Pathways

    MAPK Signaling, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
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