MAP2K7 antibody (pThr275) (AbBy Fluor® 350)

Catalog No. ABIN6976780

This Rabbit Polyclonal antibody specifically detects MAP2K7 in WB, IF (cc) and IF (p). It exhibits reactivity toward Rat.

Quick Overview for MAP2K7 antibody (pThr275) (AbBy Fluor® 350) (ABIN6976780)

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP2K7 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MAP2K7 Antibody (AbBy Fluor® 350)

Binding Specificity: pThr275

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human MEK7 around the phosphorylation site of Thr275

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MAP2K7

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Alternative Name: MEK7

Background:

Synonyms: MEK7 (phospho T275), MEK7 (phospho S275), p-MEK7 (phospho S275), c-Jun N-terminal kinase kinase 2, Dual specificity mitogen activated protein kinase kinase 7, Dual specificity mitogen-activated protein kinase kinase 7, JNK activating kinase 2, JNK kinase 2, JNK-activating kinase 2, Jnkk 2, Jnkk-2, Jnkk2, MAP kinase kinase 7, MAP2K7, MAPK/ERK kinase 7, MAPKK 7, MAPKK-7, MAPKK7, MEK 7, Mitogen Activated Protein Kinase kinase 7, MKK 7, MKK-7, MKK7, MP2K7_HUMAN, PRKMK 7, PRKMK-7, PRKMK7, Sek 2, Sek-2, Sek2.

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008].

Gene ID: 5609

UniProt: O14733

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling