STK24 antibody (pThr178) (AbBy Fluor® 488)

Catalog No. ABIN6977285

The Rabbit Polyclonal anti-STK24 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect STK24 in samples from Mouse and Rat.

Quick Overview for STK24 antibody (pThr178) (AbBy Fluor® 488) (ABIN6977285)

Target: STK24 (serine/threonine Kinase 24 (STK24))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK24 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-STK24 Antibody (AbBy Fluor® 488)

Binding Specificity: pThr178

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human MST3 around the phosphorylation site of Thr178

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for STK24

Target: STK24 (serine/threonine Kinase 24 (STK24))

Alternative Name: MST3

Background:

Synonyms: MST3 (phospho T178), p-MST3 (phospho T178), Kinase responsive to stress 1, KRS1, Mammalian STE20 like protein kinase 2, Mammalian sterile 20-like 2, Mess1, MST, MST-2, MST2, Mst3, Serine/threonine kinase 3 (STE20 homolog, yeast), Serine/threonine kinase 3 (Ste20, yeast homolog), Serine/threonine protein kinase 3, Serine/threonine protein kinase Krs1, STE20 like kinase MST2.

Background: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene ID: 8428

UniProt: Q9Y6E0