OMA1 antibody (AA 401-500) (AbBy Fluor® 488)

Catalog No. ABIN6977710

This Rabbit Polyclonal antibody specifically detects OMA1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for OMA1 antibody (AA 401-500) (AbBy Fluor® 488) (ABIN6977710)

Target: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OMA1 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-OMA1 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 401-500

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Pig,Horse,Chicken,Cat,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OMA1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for OMA1

Target: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Alternative Name: OMA1

Background:

Synonyms: Metalloendopeptidase OMA1, mitochondrial, OMA1, Metalloprotease-related protein 1, MPRP-1, Overlapping with the m-AAA protease 1 homolog, OMA1, MPRP1

Background: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.

Gene ID: 115209

UniProt: Q96E52