CMKLR1 antibody (AA 171-280) (AbBy Fluor® 750)

Catalog No. ABIN6981594

This anti-CMKLR1 antibody is a Rabbit Polyclonal antibody detecting CMKLR1 in WB, IF (cc) and IF (p). Suitable for Human and Mouse.

Quick Overview for CMKLR1 antibody (AA 171-280) (AbBy Fluor® 750) (ABIN6981594)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMKLR1 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CMKLR1 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 171-280

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Dog,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CMKLR1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: CMKLR1

Background:

Synonyms: Chemokine receptor-like 1, CHEMR23, ChemR23, DEZ, Chemokine like receptor 1, G protein coupled receptor ChemR23, G protein coupled receptor DEZ, CML1_HUMAN , Orphan G protein coupled receptor.

Background: Chemokine-Like Receptor 1 (CMKLR1) is a serpentine transmembrane G-protein linked receptor. It is an orphan chemoattractant receptor, also known as ChemR23 or DEZ. CMKLR1 is expressed on the surface of monocyte-derived immature dendritic cells and peripheral plamacytoid dendritic (pDC) cells, but not on myeloid dendritic (mDC) cells, monocytes and lymphocytes. The expression of CMKLR1 on pDC is down-regulated after activation. Chemerin (TIG2) is a natural ligand of CMKLR1. The interaction of CMKLR1 with Chemerin induces pDC activation and chemotaxis. It has been shown that CMKLR1 is a coreceptor for several strains of SIV and HIV-1. CMKLR1 is a potential useful marker for distinguishing pDCs and mDCs.

Gene ID: 1240