C5 antibody (AA 678-751) (Biotin)

Catalog No. ABIN6982560

This anti-C5 antibody is a Rabbit Polyclonal antibody detecting C5 in ELISA, IHC (p) and IHC (fro). Suitable for Human.

Quick Overview for C5 antibody (AA 678-751) (Biotin) (ABIN6982560)

Target: C5 (Complement Component 5 (C5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-C5 Antibody (Biotin)

Binding Specificity: AA 678-751

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C5a anaphylatoxin

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: C5a anaphylatoxin

Background:

Synonyms: Anaphylatoxin C5a, C5, Complement C5, Complement C5 precursor, Complement component 5, CPAMD4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5 alpha chain, C5a anaphylatoxin, Complement C5 alpha' chain, CO5_HUMAN.

Background: The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].

Gene ID: 727

UniProt: P01031

Pathways: Complement System, Carbohydrate Homeostasis