ERO1L antibody (AA 321-420) (FITC)

Catalog No. ABIN6986644

This Rabbit Polyclonal antibody specifically detects ERO1L in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for ERO1L antibody (AA 321-420) (FITC) (ABIN6986644)

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERO1L antibody is conjugated to FITC

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-ERO1L Antibody (FITC)

Binding Specificity: AA 321-420

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERO1L

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ERO1L

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Alternative Name: ERO1L

Background:

Synonyms: ERO1-like protein alpha, ERO1A, ERO1-L, ERO1-L-alpha, Endoplasmic oxidoreductin-1-like protein, Endoplasmic reticulum oxidoreductase alpha, Oxidoreductin-1-L-alpha, ERO1L

Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

Gene ID: 30001

UniProt: Q96HE7

Pathways: Peptide Hormone Metabolism, ER-Nucleus Signaling, Brown Fat Cell Differentiation