ERO1L antibody (AA 24-260)

Catalog No. ABIN7152002

Product Details anti-ERO1L Antibody

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Binding Specificity: AA 24-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERO1L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human ERO1-like protein alpha protein (24-260AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERO1L

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Alternative Name: ERO1A (ERO1L Products)

Synonyms: ERO1-L antibody, ero1-alpha antibody, ero1lb antibody, ERO1L antibody, ero1l antibody, ERO1-alpha antibody, ERO1A antibody, zgc:63959 antibody, endoplasmic reticulum oxidoreductase alpha L homeolog antibody, endoplasmic reticulum oxidoreductase 1 alpha antibody, endoplasmic reticulum oxidoreductase alpha antibody, ERO1-like (S. cerevisiae) antibody, ero1a.L antibody, ERO1A antibody, ero1a antibody, Ero1l antibody, Ero1a antibody

Background:

Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

Aliases: Endoplasmic oxidoreductin 1 like protein antibody, Endoplasmic oxidoreductin-1-like protein antibody, Endoplasmic reticulum oxidoreductase 1 alpha antibody, Endoplasmic reticulum oxidoreductin 1-like antibody, ERO1 alpha antibody, ERO1 L antibody, ERO1 Lalpha antibody, ERO1 like protein alpha antibody, ERO1-alpha antibody, ERO1-L antibody, ERO1-L-alpha antibody, ERO1-like (S. cerevisiae) antibody, ERO1-like alpha antibody, ERO1-like protein alpha antibody, ERO1-like, S. cerevisiae, homolog of, alpha antibody, ERO1A antibody, ERO1A_HUMAN antibody, ERO1L antibody, ERO1LA antibody, Oxidoreductin 1 Lalpha antibody, Oxidoreductin-1-L-alpha antibody, PRO865 antibody, UNQ434 antibody

UniProt: Q96HE7

Pathways: Peptide Hormone Metabolism, ER-Nucleus Signaling, Brown Fat Cell Differentiation