RRAGA + RRAGB (AA 231-313) antibody (HRP)
Quick Overview for RRAGA + RRAGB (AA 231-313) antibody (HRP) (ABIN6987496)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 231-313
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Cross-Reactivity
- Mouse, Rat
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Predicted Reactivity
- Human,Dog,Sheep,Pig,Horse
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human RRAGA and RRAGB
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Isotype
- IgG
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Application Notes
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IHC-P 1:200-400
IHC-F 1:100-500 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Expiry Date
- 12 months
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- RRAGA + RRAGB
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Background
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Synonyms: FIP1, RAGA, FIP-1, RRAGB, Adenovirus E3 14.7 kDa-interacting protein 1, Rag A, RAg B, RagA, RAGB, Ras related GTP binding protein A, RRAGA_HUMAN, Ras-related GTP binding A? GTP-binding protein ragB, Rag B, RagB, Ras-related GTP-binding protein B, RRAGB, RRAGB_HUMAN..
Background: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
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Gene ID
- 10670
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UniProt
- Q7L523
Target
-
