PSME3 antibody (AA 181-254) (HRP)

Catalog No. ABIN6987768

This anti-PSME3 antibody is a Rabbit Polyclonal antibody detecting PSME3 in IHC (p). Suitable for Rat.

Quick Overview for PSME3 antibody (AA 181-254) (HRP) (ABIN6987768)

Target: PSME3

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME3 antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PSME3 Antibody (HRP)

Binding Specificity: AA 181-254

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PSME3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PSME3

Target: PSME3

Alternative Name: PSME3

Background:

Synonyms: PA28G, 11S regulator complex gamma subunit, 11S regulator complex subunit gamma, Activator of multicatalytic protease subunit 3, Ki antibody Ki antigen, Ki nuclear autoantigen, Ki, PA28 gamma, PA28 gamma, PA28gamma, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki), Proteasome (prosome, macropain) activator subunit 3, Proteasome activator 28 gamma, Proteasome activator 28 subunit gamma, Proteasome activator complex subunit 3, Proteasome activator subunit 3, PSME3, PSME3_HUMAN,

Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

Gene ID: 10197

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA