PLK4 antibody

Catalog No. ABIN6988991

The Rabbit Polyclonal anti-PLK4 antibody has been validated for IHC (p). It is suitable to detect PLK4 in samples from Human.

Quick Overview for PLK4 antibody (ABIN6988991)

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLK4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PLK4 Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PLK4/STK18

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PLK4

Target: PLK4 (Polo-Like Kinase 4 (PLK4))

Alternative Name: PLK4/STK18

Target Type: Phage Protein

Background:

Synonyms: PLK 4, PLK-4, PLK4_HUMAN, Polo like Kinase 4, Polo-like kinase 4, Protein serine/threonine kinase, SAK, Serine/Threonine Kinase 18, Serine/threonine kinase, Serine/threonine protein kinase 18, Serine/threonine protein kinase PLK4, Serine/threonine protein kinase Sak, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SAK, Snk Akin Kinase, STK 18.

Background: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.

Gene ID: 10733

UniProt: O00444

Pathways: M Phase