PLA2G6 antibody (AA 331-430)

Catalog No. ABIN6989060

The Rabbit Polyclonal anti-PLA2G6 antibody is suitable to detect PLA2G6 in samples from Rat and Mouse. It has been validated for ICC, IHC (p), IHC (fro) and IF.

Quick Overview for PLA2G6 antibody (AA 331-430) (ABIN6989060)

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G6 antibody is un-conjugated

Application: Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Product Details anti-PLA2G6 Antibody

Binding Specificity: AA 331-430

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CaIPLA2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500
IF()
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PLA2G6

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Alternative Name: CaIPLA2

Background:

Synonyms: 85 kDa calcium independent phospholipase A2, 85 kDa calcium-independent phospholipase A2, CaI PLA2, CaI-PLA2, CaIPLA2, Calcium independent phospholipase A2, Cytosolic calcium independent phospholipase A2, Group VI phospholipase A2, GVI, GVI PLA2, INAD1, iPLA(2)beta, iPLA2, IPLA2 VIA, iPLA2beta, NBIA2A, NBIA2B, PA2G6_HUMAN, PARK14, Patatin like phospholipase domain containing 9, Patatin like phospholipase domain containing protein 9, Phospholipase A2 calcium independent, Phospholipase A2 calcium independent group VI A, Phospholipase A2 group VI, Phospholipase A2 group VI cytosolic calcium independent, PLA2, PLA2G6, PNPLA9, PLPL9_HUMAN

Background: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Gene ID: 8398

UniProt: O60733

Pathways: Positive Regulation of Peptide Hormone Secretion