KDM1B antibody (AA 51-150)

Catalog No. ABIN6989407

This Rabbit Polyclonal antibody specifically detects KDM1B in ELISA, ICC, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Mouse and Rat.

Quick Overview for KDM1B antibody (AA 51-150) (ABIN6989407)

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM1B antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-KDM1B Antibody

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LSD2 / AOF1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for KDM1B

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Alternative Name: LSD2 / AOF1

Background:

Synonyms: LSD2 / AOF1, KDM1B, amine oxidase (flavin containing) domain 1, amine oxidase, flavin containing 1, AOF1, bA204B7.3, C6orf193, dJ298J15.2, Flavin-containing amine oxidase domain-containing protein 1, FLJ33898, FLJ34109, FLJ43328, KDM1B, KDM1B_HUMAN, LSD2, lysine (K)-specific demethylase 1B, Lysine-specific demethylase 2, Lysine-specific histone demethylase 1B, Lysine-specific histone demethylase 2.

Background: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.

Gene ID: 221656

UniProt: Q8NB78

Pathways: Warburg Effect