SMAD9 antibody (AA 351-450)

Catalog No. ABIN6989418

The Rabbit Polyclonal anti-SMAD9 antibody (ABIN6989418) specifically detects SMAD9 in IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for SMAD9 antibody (AA 351-450) (ABIN6989418)

Target: SMAD9 (SMAD Family Member 9 (SMAD9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD9 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SMAD9 Antibody

Binding Specificity: AA 351-450

Purpose: SMAD8/SMAD9 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SMAD8

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SMAD9

Target: SMAD9 (SMAD Family Member 9 (SMAD9))

Alternative Name: SMAD8

Background:

Synonyms: AI528653 , BSP 1 , BSP1 , DKFZp781C1895 , DKFZp781O1323 , Dwarfin A , Dwf A , DwfA , Dwfc , hSMAD1 , hSmad5 , JV 41 , JV4 1 , JV41 , JV5 1 , MAD (mothers against decapentaplegic, Drosophila) homolog 1 , MAD (mothers against decapentaplegic, Drosophila) homolog 9 , MAD homolog 1 , MAD homolog 9 , MAD homolog1 (mothers against decapentaplegic, Drosophila) ,

Background: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway

Gene ID: 142891

UniProt: Q96LT4