ERBB3 antibody (pTyr1222)

Catalog No. ABIN6989639

The Rabbit Monoclonal anti-ERBB3 antibody has been validated for WB and IHC (p). It is suitable to detect ERBB3 in samples from Human.

Quick Overview for ERBB3 antibody (pTyr1222) (ABIN6989639)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5F9

Product Details anti-ERBB3 Antibody

Binding Specificity: pTyr1222

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Synthetic phosphoPeptide corresponding to a region surrounding Tyrosine 1222 of Human ErbB3.

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: HER3/ErbB3

Background:

Synonyms: c erbB 3 antibody, c erbB3 antibody, Erb b2 receptor tyrosine kinase 3 antibody, ErbB 3 antibody, ERBB3 antibody, ERBB3 protein antibody, erbB3 S antibody, ERBB3_HUMAN antibody, Glial growth factor receptor antibody, HER 3 antibody, HER3 antibody, Human epidermal growth factor receptor 3 antibody, LCCS2 antibody, MDA BF 1 antibody, MGC88033 antibody, p180 ErbB3 antibody, p45 sErbB3 antibody, p85 sErbB3 antibody, proto-oncogene-like protein c ErbB 3 antibody, proto-oncogene-like protein c ErbB3 antibody, Proto-oncogene-like protein c-ErbB-3 antibody, Receptor tyrosine protein kinase erbB 3 antibody, Receptor tyrosine protein kinase erbB3 antibody, Receptor tyrosine-protein kinase erbB-3 antibody, Tyrosine kinase type cell surface receptor HER3 antibody, Tyrosine kinase-type cell surface receptor HER3 antibody, v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody, v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

Background: The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Gene ID: 2065

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway