ERAP1 antibody

Catalog No. ABIN6989656

This Rabbit Monoclonal antibody specifically detects ERAP1 in WB. It exhibits reactivity toward Human.

Quick Overview for ERAP1 antibody (ABIN6989656)

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3H62

Product Details anti-ERAP1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Synthetic Peptide corresponding to C-terminal human ERAP1.

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ERAP1

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Alternative Name: ERAP1

Background:

Synonyms: A LAP antibody, A-LAP antibody, Adipocyte derived leucine aminopeptidase antibody, Adipocyte-derived leucine aminopeptidase antibody, ALAP antibody, Aminopeptidase PILS antibody, Aminopeptidase regulator of TNFR1 shedding antibody, APPILS antibody, ARTS 1 antibody, ARTS-1 antibody, Arts1 antibody, Endoplasmic reticulum aminopeptidase 1 antibody, Endoplasmic reticulum aminopeptidase associated with antigen processing antibody, ERAAP antibody, ERAAP1 antibody, ERAP 1 antibody, Erap1 antibody, ERAP1_HUMAN antibody, KIAA0525 antibody, kiaa0525 protein antibody, PILS AP antibody, PILS-AP antibody, PILSA antibody, PILSAP antibody, Puromycin insensitive leucyl specific aminopeptidase antibody, Puromycin-insensitive leucyl-specific aminopeptidase antibody, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody, type 1 tumor necrosis factor receptors shedding aminopeptidase regulator antibody, VEGF-induced aminopeptidase antibody

Background: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Gene ID: 51752

UniProt: Q9NZ08