Hax1a (N-Term) antibody

Catalog No. ABIN6990185

The Mouse Monoclonal anti-Hax1a antibody is suitable to detect Hax1a in samples from Human and Rat. It has been validated for ELISA and WB.

Quick Overview for Hax1a (N-Term) antibody (ABIN6990185)

Target: Hax1a

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Clone: 9F3D11

Product Details

Binding Specificity: N-Term

Purification: Hax1a Monoclonal Antibody is Protein G purified.

Immunogen: Mouse monoclonal Hax1a antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human Hax1a.

Isotype: IgG3

Application Details

Application Notes: Hax1a antibody can be used for detection of Hax1A by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Hax1a Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Hax1a monoclonal antibody can be stored at -20°C, stable for one year.

Target Details

Target: Hax1a

Background: Hax1a Monoclonal Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting. At least four isoforms of Hax1 are known to exist. This antibody is expected to recognize the longest isoform (Hax1a) as well as the shortest.

Gene ID: 10456

NCBI Accession: NP_006109

UniProt: O00165