LY96 antibody (AA 2-160)

Catalog No. ABIN6990190

This Mouse Monoclonal antibody specifically detects LY96 in WB, ELISA, ICC, IHC (p) and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LY96 antibody (AA 2-160) (ABIN6990190)

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY96 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: 1A2E3

Product Details anti-LY96 Antibody

Binding Specificity: AA 2-160

Purification: MD-2 Monoclonal Antibody is Protein A purified.

Immunogen: Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2.

Isotype: IgG1

Application Details

Application Notes: MD-2 antibody can be used for detection of MD-2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in recombinnat protein, Immunohistochemistry in human samples, Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: MD-2 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: MD-2 monoclonal antibody can be stored at -20°C, stable for one year.

Target Details for LY96

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Alternative Name: MD-2

Background: MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2, e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Gene ID: 23643

NCBI Accession: NP_056179

UniProt: Q9Y6Y9

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades