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SKI antibody (N-Term)

SKI Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990332
  • Target See all SKI Antibodies
    SKI (SKI Proto-Oncogene (SKI))
    Binding Specificity
    • 7
    • 3
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 25
    • 20
    • 11
    • 3
    • 3
    Human
    Host
    • 22
    • 3
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SKI antibody is un-conjugated
    Application
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Purification
    Ski Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Ski antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Ski. The immunogen is located within the first 50 amino acids of Ski.
    Isotype
    IgG
    Top Product
    Discover our top product SKI Primary Antibody
  • Application Notes
    SkiP antibody can be used for detection of Ski by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Ski Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    Ski antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SKI (SKI Proto-Oncogene (SKI))
    Alternative Name
    Ski (SKI Products)
    Synonyms
    SGS antibody, SKV antibody, SKI antibody, C-SKI antibody, RGD1565591 antibody, c-ski antibody, 2310012I02Rik antibody, 2610001A11Rik antibody, AA062172 antibody, AA589460 antibody, BC004088 antibody, ski antibody, skv antibody, xski antibody, id:ibd1250 antibody, SKI proto-oncogene antibody, ski sarcoma viral oncogene homolog (avian) antibody, SKI proto-oncogene L homeolog antibody, v-ski avian sarcoma viral oncogene homolog a antibody, SKI antibody, Ski antibody, ski.L antibody, skia antibody
    Background
    Ski Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
    Gene ID
    6497
    UniProt
    P12755
    Pathways
    Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development
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