IL21 Receptor antibody (AA 80-130)

Catalog No. ABIN6990374

The Rabbit Polyclonal anti-IL21 Receptor antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect IL21 Receptor in samples from Human, Mouse and Rat.

Quick Overview for IL21 Receptor antibody (AA 80-130) (ABIN6990374)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL21 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL21 Receptor Antibody

Binding Specificity: AA 80-130

Purification: IL-21 Receptor Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor. The immunogen is located within amino acids 80 - 130 of IL-21 Receptor.

Isotype: IgG

Application Details

Application Notes: IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 1-2 μ,g/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-21 Receptor Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-21 Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL-21 Receptor

Background: IL-21 Receptor Antibody: A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

Molecular Weight: Predicted: 60 kDa

Observed: 62 kDa        

Gene ID: 50615

NCBI Accession: NP_068570

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling