PCBP4 antibody (C-Term)

Catalog No. ABIN6990376

This Rabbit Polyclonal antibody specifically detects PCBP4 in ELISA, WB, ICC and IF. It exhibits reactivity toward Human.

Quick Overview for PCBP4 antibody (C-Term) (ABIN6990376)

Target: PCBP4 (Poly(rC) Binding Protein 4 (PCBP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCBP4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-PCBP4 Antibody

Binding Specificity: C-Term

Purification: MCG10 Antibody is affinity chromatography purified via peptide column.

Immunogen: MCG10 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human MCG10. The immunogen is located within the last 50 amino acids of MCG10.

Isotype: IgG

Application Details

Application Notes: MCG10 antibody can be used for detection of MCG10 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: MCG10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: MCG10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PCBP4

Target: PCBP4 (Poly(rC) Binding Protein 4 (PCBP4))

Alternative Name: MCG10

Background: MCG10 Antibody: MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.

Gene ID: 57060

UniProt: P57723