DEDD2 antibody (N-Term)

Catalog No. ABIN6990411

This anti-DEDD2 antibody is a Rabbit Polyclonal antibody detecting DEDD2 in WB and ELISA. Suitable for Human, Rat and Mouse.

Quick Overview for DEDD2 antibody (N-Term) (ABIN6990411)

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEDD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DEDD2 Antibody

Binding Specificity: N-Term

Purification: DEDD2 Antibody is immunoaffinity chromatography purified IgG.

Immunogen: DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2. The immunogen is located within the first 50 amino acids of DEDD2.

Isotype: IgG

Application Details

Application Notes: DEDD2 antibody can be used for detection of DEDD2 by Western blot at 0.5 to 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DEDD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DEDD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DEDD2

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Alternative Name: DEDD2

Background: DEDD2 Antibody: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

Gene ID: 162989

NCBI Accession: NP_579874

UniProt: Q8WXF8