BCL2L10 antibody (N-Term)

Catalog No. ABIN6990431

The Rabbit Polyclonal anti-BCL2L10 antibody has been validated for WB, ELISA and ICC. It is suitable to detect BCL2L10 in samples from Human.

Quick Overview for BCL2L10 antibody (N-Term) (ABIN6990431)

Target: BCL2L10 (BCL2-Like 10 (Apoptosis Facilitator) (BCL2L10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-BCL2L10 Antibody

Binding Specificity: AA 90-140, N-Term

Purification: Bcl-B Antibody is affinity chromatography purified via peptide column.

Immunogen: Bcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B. The immunogen is located within amino acids 90 - 140 of Bcl-B.

Isotype: IgG

Application Details

Application Notes: Bcl-B antibody can be used for the detection of Bcl-B by Western blot at 1 - 2 μ,g/mL. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bcl-B Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bcl-B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BCL2L10

Target: BCL2L10 (BCL2-Like 10 (Apoptosis Facilitator) (BCL2L10))

Alternative Name: Bcl-B

Background: Bcl-B Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1.

Molecular Weight: Predicted: 22 kDa

Observed: 26 kDa

Gene ID: 10017

NCBI Accession: NP_065129

UniProt: Q9HD36

Pathways: Positive Regulation of Endopeptidase Activity