BCL2L1 antibody (C-Term)

Catalog No. ABIN6990472

This Rabbit Polyclonal antibody specifically detects BCL2L1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for BCL2L1 antibody (C-Term) (ABIN6990472)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BCL2L1 Antibody

Binding Specificity: C-Term

Purification: Bcl-xL Antibody is supplied as ion exchange chromatography purified IgG.

Immunogen: Bcl-xL antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human Bcl-xL. The immunogen is located within the last 50 amino acids of Bcl-xL.

Isotype: IgG

Application Details

Application Notes: Bcl-xL antibody can be used for detection of Bcl-xL by Western blot at 1 to 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bcl-xL Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bcl-xL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Alternative Name: Bcl-xL

Background: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

Gene ID: 598

UniProt: Q07817

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling