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IRF3 antibody (C-Term)

The Rabbit Polyclonal anti-IRF3 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect IRF3 in samples from Human and Mouse.
Catalog No. ABIN6990491

Quick Overview for IRF3 antibody (C-Term) (ABIN6990491)

Target

See all IRF3 Antibodies
IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivity

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Human, Mouse

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This IRF3 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Binding Specificity

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    AA 330-380, C-Term

    Specificity

    At least three isoforms of IRF3 are known to exist.

    Purification

    IRF3 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    IRF3 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human IRF3. The immunogen is located within amino acids 330 - 380 of IRF3.

    Isotype

    IgG
  • Application Notes

    IRF3 antibody can be used for detection of IRF3 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    IRF3 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    IRF3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    IRF3 (Interferon Regulatory Factor 3 (IRF3))

    Alternative Name

    IRF3

    Background

    IRF3 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by Iκ,B kinase-ε, and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms.

    Molecular Weight

    43, 47, 50 kDa

    Gene ID

    3661

    NCBI Accession

    NP_001562

    UniProt

    Q14653

    Pathways

    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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