Caspase 6 antibody (N-Term)

Catalog No. ABIN6990523

This Rabbit Polyclonal antibody specifically detects Caspase 6 in WB, ELISA and ICC. It exhibits reactivity toward Human.

Quick Overview for Caspase 6 antibody (N-Term) (ABIN6990523)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-Caspase 6 Antibody

Binding Specificity: N-Term

Specificity: Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.

Purification: Caspase-6 Antibody is affinity chromatography purified via peptide column.

Immunogen: Caspase-6 antibody was raised against a 15 amino acid synthetic peptide from near the amino-terminus of human Caspase-6. The immunogen is located within the first 50 amino acids of Caspase-6.

Isotype: IgG

Application Details

Application Notes: Caspase-6 antibody can be used for the detection of caspase-6 by Western blot at 0.5 to 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Caspase-6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Caspase-6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: Caspase-6

Background: Caspase-6 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was idientifed based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.

Gene ID: 839

NCBI Accession: NP_001217

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis